Livedoid vasculitis
Livedoid vasculitis ھڪ دائمي چمڙيءَ جي بيماري آھي جيڪا اڪثر ڪري نوجوان کان وچين عمر جي عورتن ۾ ٿيندي آھي. ان جي خاصيتن کي بيان ڪرڻ لاءِ هڪ مخفف استعمال ڪيو ويو آهي "Painful purpuric ulcers with the reticular pattern of the Lower extremities" (PURPLE). اهو ڪيترن ئي بيمارين سان جڙيل آهي، جن ۾ دائمي وينس هائپر ٽائونشن ۽ ويريڪوسيٽس شامل آهن.
☆ 2022 ۾ جرمني مان Stiftung Warentest نتيجن، ModelDerm سان صارفين جي اطمينان صرف ادا ڪيل ٽيلي ميڊيسن مشوري جي ڀيٽ ۾ ٿورو گهٽ هئي.
اهو درد سان گڏ ٿي سگهي ٿو.
References
Livedoid vasculopathy هڪ نادر چمڙي جي حالت آهي جنهن جي خاصيت دردناڪ السر جي ڪري ٿي جيڪا هيٺئين پيرن تي واپس ايندي رهي ٿي.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy چمڙي جي هڪ نادر حالت آهي جيڪا هيٺين پيرن تي بار بار السر جو سبب بڻجندي آهي، پويان پيلا داغ ڇڏي ويندا آهن جن کي Atrophie Blanche سڏيو ويندو آهي. جڏهن ته صحيح سبب اڃا تائين واضح نه آهي، اهو يقين آهي ته رت جي ٺهڻ ۾ اضافو (hypercoagulability) بنيادي عنصر آهي، جنهن ۾ سوزش هڪ ثانوي ڪردار ادا ڪري ٿي. ڪلٽنگ ۾ حصو وٺندڙ عنصر هن ريت آهن - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. بايوپسيز ۾، حالت ڏيکاري ٿي رت جي ڪلٽون اندرين، ويسلن جي ڀتين جي ٿلهي، ۽ زخم. علاج ۾ هڪ گھڻائي وارو طريقو شامل آهي جنهن ۾ رت جي ڪلٽن کي روڪڻ تي ڌيان ڏنو وڃي ٿو دوائن جهڙوڪ اينٽي پليٽليٽ دوائن، رت کي پتلي ڪندڙ، ۽ فائبرنولائيٽ علاج. هن چمڙي جي حالت لاءِ مختلف دوائون استعمال ڪري سگهجن ٿيون - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy هڪ نادر حالت آهي جتي زخم ٻنهي پيرن تي ٿينديون آهن. ننڍڙن رت جي نالن ۾ رت جي ڪلٽن جي ٺهڻ جو سبب سمجهيو ويندو آهي ڪلٽنگ وڌڻ ۽ رت جي ڦاٽن جي گھٽتائي سان، ويسلن جي استر کي نقصان سان. اهو عورتن ۾ وڌيڪ عام آهي، خاص طور تي 15 ۽ 50 سالن جي وچ ۾. تماڪ ڇڏڻ، زخمن جو خيال رکڻ، ۽ دوائن جو استعمال جهڙوڪ رت کي پتلي ڪندڙ ۽ اينٽي پليٽليٽ دوائن جو استعمال اثرائتو ثابت ٿيو آهي.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
